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In rodents, the upper sensitivity can also be related to a shorter plasma half-life of T four than in people due to considerable differences between species within the transport proteins for thyroid hormones. In plasma, the T 4 half-life is about 12—24 h in rats vs 5—9 days in people, and the serum levels of TSH are about 25 instances larger in rodents than in humans.
Fifty per cent of survivors have been sacrificed 1 week later, and blood and urine samples were taken. http://www.docspal.com/viewer?id=- confirmed a focus-dependent increase in labelling index [ three H]thymidine , acanthosis, and papillomatosis. After software of an ointment containing To research the goitrogenic exercise of resorcinol, feminine Wistar rats had been treated twice daily for 28 days by rubbing 6 g of an ointment containing Increased thyroid gland weights 2.
Determination of resorcinol conjugates within the h urine samples after 14 days of continuous product treatment confirmed that a maximal 23 mg 2. Assuming a body weight of 64 kg IPCS, provides an publicity estimate of zero. In a report primarily based on consumer research data Gans, , beneath reasonable maximum-use conditions i.
Hence, an improved biodegradation fee results in reduced risks for the surroundings. Regarding the consequences of resorcinol on aquatic species, the toxicity knowledge set includes a variety of species from different trophic ranges. Results from tests with totally different aquatic species from different trophic ranges are available for the acute toxicity of resorcinol to aquatic organisms.
More ordinary-use circumstances would end in exposures of about zero. Further particulars were not given.
https://www.scribd.com/ that died confirmed hyperaemia and distension of abdomen and intestine, while there have been no gross lesions at necropsy in survivors Flickinger, In one other research with CFY rats. Most of the studies are of sufficient quality and acceptable for risk characterization functions.
Resorcinol is understood to kind covalent bonds with haem Sessler et al. Effects on the thyroid gland have been reported both in animal research and in case-reports in people. However, there are species variations in the susceptibility to goitrogens.
